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4-Fluoroamphetamine (4-FA4-FMPPAL-303; “Flux“), also known as para-fluoroamphetamine (PFA) is a psychoactive research chemical of the phenethylamine and substituted amphetamine chemical classes. It produces stimulant and entactogenic effects, and is described subjectively as being between amphetamine and MDMA. As a recreational drug, 4-FA is sometimes sold along with related compounds such as 2-fluoroamphetamine and 4-fluoromethamphetamine. BUY 4-Fluoroamphetamine Crystal online

4-Fluoroamphetamine is a substituted amphetamine that offers effects somewhere between those of amphetamine and MDMA. It’s been a member of the research chemical market since the late 2000s.

It has at times been a more popular research chemical because it does have a unique and potentially desirable effect profile.

Not enough is known about the drug to be sure about its safety level, particularly with chronic use.

Usage

4-Fluoroamphetamine (4-FA) is popular in the Netherlands where it is predominantly used for its specific effects (77% of users) rather than its legal status (18%). 4-FA has become illegal since May 2017.

Toxicology

The LD50 (mouse; i.p.) of 4-FA is 46 mg/kg.

4-FA has only been involved in one death worldwide, where it was combined with amphetamine, methadone and benzodiazepines.

Pharmacology

4-Fluoroamphetamine is a releasing agent and reuptake inhibitor of dopamine, serotonin, and norepinephrine. The respective EC50 values are 2.0 x 10−7 M, 7.3 x 10−7 M, and 0.37 x 10−7 M, while the IC50 values are 7.7 x 10−7 M, 68 x 10−7 M, and 4.2 x 10−7 M.

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3,4-DMMC Powder also call 3,4-Dimethylmethcathinone is a stimulant drug first reported in 2010 as a designer drug analogue of mephedrone, apparently produced in response to the banning of mephedrone, following its widespread abuse in many countries in Europe and around the world. 3,4-DMMC has been seized as a designer drug in Australia. Buy 3,4-DMMC Powder Online

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Legal Status

As of October 2015 3,4-DMMC is a controlled substance in China.

3,4-DMMC is banned in the Czech Republic.

Chemical and physical data

Formula: C12H17NO

Molar mass: 191.269 g/mol g·mol−1

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Buy Etizolam Powder Online

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Buy Etizolam Powder Online

Etizolam (marketed under many brand names) is a thienodiazepine derivative which is a benzodiazepine analog. The etizolam molecule differs from a benzodiazepine in that the benzene ring has been replaced by a thiophene ring and triazole ring has been fused, making the drug a thienotriazolodiazepine. It possesses amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. Buy Etizolam Powder Online

It was patented in 1972 and approved for medical use in 1983.

Pharmacology

Etizolam pills

Etizolam, a thienodiazepine derivative, is absorbed fairly rapidly, with peak plasma levels achieved between 30 minutes and 2 hours. It has a mean elimination half life of about 3.5 hours. Etizolam possesses potent hypnotic properties, and is comparable with other short-acting benzodiazepines. Etizolam acts as a full agonist at the benzodiazepine receptor to produce its range of therapeutic and adverse effects.

According to the Italian P.I. sheet, etizolam belongs to a new class of diazepines, thienotriazolodiazepines. This new class is easily oxidized, rapidly metabolized, and has a lower risk of accumulation, even after prolonged treatment. Etizolam has an anxiolytic action about 6 times greater than that of diazepam. Etizolam produces, especially at higher dosages, a reduction in time taken to fall asleep, an increase in total sleep time, and a reduction in the number of awakenings. During tests, there were no substantial changes in deep sleep; however, it may reduce REM sleep. In EEG tests of healthy volunteers, etizolam showed some similar characteristics to tricyclic antidepressants.

Interactions

Itraconazole and fluvoxamine slow down the rate of elimination of etizolam, leading to accumulation of etizolam, therefore increasing its pharmacological effects. Carbamazepine speeds up the metabolism of etizolam, resulting in reduced pharmacological effects.

Overdose

Cases of intentional suicide by overdose using etizolam in combination with GABA agonists have been reported. Although etizolam has a lower LD50 than certain benzodiazepines, the LD50 is still far beyond the prescribed or recommended dose. Flumazenil, a GABA antagonist agent used to reverse benzodiazepine overdoses, inhibits the effect of etizolam as well as classical benzodiazepines such as diazepam and chlordiazepoxide.

Etizolam overdose deaths are rising – for instance, the National Records of Scotland report on drug-related deaths, implicated 548 deaths from ‘street’ Etizolam in 2018, almost double the number from 2017 (299) and only six years from the first recorded death (in 2012). The 548 deaths were 45% of all drug-related deaths in Scotland in 2018.

Chemical and physical data

Formula: C17H15ClN4S

Molar mass: 342.07 g/mol g·mol−1

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Buy 5F-PB22 Crystal Online

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Buy 5F-PB22 Crystal Online

Buy 5F-PB22 Crystal is a designer drug which acts as a cannabinoid agonist. The structure of 5F-PB-22 appears to have been designed with an understanding of structure–activity relationships within the indole class of cannabinoids. Buy 5F-PB22 Crystal Online

5-fluoro PB-22 (Item No. 14095) is an analytical reference material that is structurally categorized as a synthetic cannabinoid (CB). It is a full agonist of human CB1 and CB2 receptors (pEC50s = 8.55 and 7.97, respectively).1,2 5-fluoro PB-22 potently and dose-dependently induces hypothermia and reduces heart rate in rats, mimicking the in vivo effects of Δ9-THC (Item Nos. 12068 | ISO60157).1 This product is intended for research and forensic applications.

Pharmacology

5F-PB-22 acts as a full agonist with a binding affinity of 0.468 nM at CB1 and 0.633 nM at CB2cannabinoid receptors.

Chemical and physical data
Formula: C23H21FN2O2
Molar mass: 376.431 g·mol−1

Technical Information

Formal Name : 1-(5-fluoropentyl)-8-quinolinyl ester-1H-indole-3-carboxylic acid
CAS Number : 1400742-41-7
Molecular Formula : C23H21FN2O2
Formula Weight : 376.4
Purity : ≥98%
Formulation
A neat solid
SMILES
O=C(OC1=C(N=CC=C2)C2=CC=C1)C3=CN(CCCCCF)C4=C3C=CC=C4
InChi Code
InChI=1S/C23H21FN2O2/c24-13-4-1-5-15-26-16-19(18-10-2-3-11-20(18)26)23(27)28-21-12-6-8-17-9-7-14-25-22(17)21/h2-3,6-12,14,16H,1,4-5,13,15H2
InChi Key
MBOCMBFDYVSGLJ-UHFFFAOYSA-N

WARNING This product is not for human or veterinary use.

Shipping & Storage Information
Storage: -20°C
Shipping: Room Temperature in continental US; may vary elsewhere
Stability: ≥ 3 years

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BUY Thiafentanil POWDER Online

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BUY Thiafentanil POWDER Online

Thiafentanil POWDER (A-3080Thianil) is a highly potent opioid analgesic that is an analog of fentanyl, and was invented in 1986. It is similar to carfentanil though with a faster onset of effects, shorter duration of action and a slightly lesser tendency to produce respiratory depression. It is used in veterinary medicine to anesthetise large animals such as impala, usually in combination with other anesthetics such as ketamine, xylazine or medetomidine to reduce the prevalence of side effects such as muscle rigidity. BUY Thiafentanil POWDER Online

Side effects

Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Potent pure opioid antagonists such as naltrexone or nalmefene are recommended in the event of accidental human exposure to thiafentanil. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear. A new wave of fentanyl analogues and associated deaths began in around 2014 in the US, and have continued to grow in prevalence; especially since 2016 these drugs have been responsible for hundreds of overdose deaths every week.

Legal status

Thiafentanil is a Schedule II controlled drug in the USA since August 2016.

Chemical and physical data

Formula: C22H28N2O4S

Molar mass: 416.54 g·mol−1

See also